Effects of rutin and quercetin on monooxygenase activities in experimental influenza virus infection.
Identifieur interne : 002179 ( Main/Exploration ); précédent : 002178; suivant : 002180Effects of rutin and quercetin on monooxygenase activities in experimental influenza virus infection.
Auteurs : Varban M. Savov [Bulgarie] ; Angel S. Galabov ; Lyubka P. Tantcheva ; Milka M. Mileva ; Elitsa L. Pavlova ; Emilia S. Stoeva ; Ana A. BraykovaSource :
- Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie [ 0940-2993 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Antioxydants (usage thérapeutique), Association de médicaments, Cytochrome P-450 enzyme system (métabolisme), Infections à Orthomyxoviridae (métabolisme), Infections à Orthomyxoviridae (traitement médicamenteux), Influenzavirus A (physiologie), Microsomes du foie (), Microsomes du foie (enzymologie), Mixed function oxygenases (métabolisme), Modèles animaux de maladie humaine, Mâle, NADPH-ferrihemoprotéine reductase (métabolisme), Peroxydation lipidique (physiologie), Poumon (anatomopathologie), Poumon (métabolisme), Quercétine (usage thérapeutique), Rutoside (usage thérapeutique), Souris, Souris de lignée ICR, Stress oxydatif (), Substances réactives à l'acide thiobarbiturique (métabolisme).
- MESH :
- anatomopathologie : Poumon.
- enzymologie : Microsomes du foie.
- métabolisme : Cytochrome P-450 enzyme system, Infections à Orthomyxoviridae, Mixed function oxygenases, NADPH-ferrihemoprotéine reductase, Poumon, Substances réactives à l'acide thiobarbiturique.
- physiologie : Influenzavirus A, Peroxydation lipidique.
- traitement médicamenteux : Infections à Orthomyxoviridae.
- usage thérapeutique : Antioxydants, Quercétine, Rutoside.
- Animaux, Association de médicaments, Microsomes du foie, Modèles animaux de maladie humaine, Mâle, Souris, Souris de lignée ICR, Stress oxydatif.
English descriptors
- KwdEn :
- Animals, Antioxidants (therapeutic use), Cytochrome P-450 Enzyme System (metabolism), Disease Models, Animal, Drug Therapy, Combination, Influenzavirus A (physiology), Lipid Peroxidation (physiology), Lung (metabolism), Lung (pathology), Male, Mice, Mice, Inbred ICR, Microsomes, Liver (drug effects), Microsomes, Liver (enzymology), Mixed Function Oxygenases (metabolism), NADPH-Ferrihemoprotein Reductase (metabolism), Orthomyxoviridae Infections (drug therapy), Orthomyxoviridae Infections (metabolism), Oxidative Stress (drug effects), Quercetin (therapeutic use), Rutin (therapeutic use), Thiobarbituric Acid Reactive Substances (metabolism).
- MESH :
- chemical , metabolism : Cytochrome P-450 Enzyme System, Mixed Function Oxygenases, NADPH-Ferrihemoprotein Reductase, Thiobarbituric Acid Reactive Substances.
- chemical , therapeutic use : Antioxidants, Quercetin, Rutin.
- drug effects : Microsomes, Liver, Oxidative Stress.
- drug therapy : Orthomyxoviridae Infections.
- enzymology : Microsomes, Liver.
- metabolism : Lung, Orthomyxoviridae Infections.
- pathology : Lung.
- physiology : Influenzavirus A, Lipid Peroxidation.
- Animals, Disease Models, Animal, Drug Therapy, Combination, Male, Mice, Mice, Inbred ICR.
Abstract
The aim of this work is to study the effect of the flavonoids rutin and quercetin on hepatic monooxygenase activities in experimental influenza virus infection (EIVI). EIVI causes oxidative stress in the whole organism. This is confirmed by the rapidly increased concentrations of thiobarbituric reactive substances in influenza-infected mice: lungs - 290%; blood plasma - more than 320%; liver - 230%; brain - 50%. Although known for their antioxidant activities, rutin and quercetin exhibit prooxidant effect in healthy and antioxidant activity in influenza-infected animals. The pretreatment with both flavonoids (20 mg/kg b.w.) restores oxidative damage mostly in the target organ of the infection as well as in the liver of all infected mice (lungs: rutin - 30%, quercetin - 40%, combination - 45%; liver: rutin - 12%; quercetin - 40%; combination - 50%). As far as EIVI causes oxidative stress, toxicosis and inhibition of the hepatic monooxygenase activity, it is important to study the effects of rutin and quercetin on these systems. Both flavonoids induce the level of cytochrome P-450 (rutin - 13%, quercetin - 30%, combination - 22%) but inactivate NADPH-cytochrome c reductase, aminopyrine N-demethylase and analgin N-demethylase on the 5th day of EIVI. Probably, these flavonoids affect different components of the monooxygenase system. These effects could be explained with oxidative hepatic intoxication on the 5th critical day of EIVI as well as higher dose treatment. More data are needed on the antioxidant/prooxidant effects of rutin and quercetin, probably due to specific metabolic and physiological activities, chemical structure, etc.
DOI: 10.1016/j.etp.2006.05.002
PubMed: 16793246
Affiliations:
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Le document en format XML
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Galabov</name></author><author><name sortKey="Tantcheva, Lyubka P" sort="Tantcheva, Lyubka P" uniqKey="Tantcheva L" first="Lyubka P" last="Tantcheva">Lyubka P. Tantcheva</name></author><author><name sortKey="Mileva, Milka M" sort="Mileva, Milka M" uniqKey="Mileva M" first="Milka M" last="Mileva">Milka M. Mileva</name></author><author><name sortKey="Pavlova, Elitsa L" sort="Pavlova, Elitsa L" uniqKey="Pavlova E" first="Elitsa L" last="Pavlova">Elitsa L. Pavlova</name></author><author><name sortKey="Stoeva, Emilia S" sort="Stoeva, Emilia S" uniqKey="Stoeva E" first="Emilia S" last="Stoeva">Emilia S. Stoeva</name></author><author><name sortKey="Braykova, Ana A" sort="Braykova, Ana A" uniqKey="Braykova A" first="Ana A" last="Braykova">Ana A. 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Savov</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics, Faculty of Physics, Sofia University St. Kliment Ohridski, 5 James Boucher Blvd., 1164 Sofia, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Medical Physics, Faculty of Physics, Sofia University St. Kliment Ohridski, 5 James Boucher Blvd., 1164 Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Galabov, Angel S" sort="Galabov, Angel S" uniqKey="Galabov A" first="Angel S" last="Galabov">Angel S. Galabov</name></author><author><name sortKey="Tantcheva, Lyubka P" sort="Tantcheva, Lyubka P" uniqKey="Tantcheva L" first="Lyubka P" last="Tantcheva">Lyubka P. Tantcheva</name></author><author><name sortKey="Mileva, Milka M" sort="Mileva, Milka M" uniqKey="Mileva M" first="Milka M" last="Mileva">Milka M. 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(metabolism)</term><term>Orthomyxoviridae Infections (drug therapy)</term><term>Orthomyxoviridae Infections (metabolism)</term><term>Oxidative Stress (drug effects)</term><term>Quercetin (therapeutic use)</term><term>Rutin (therapeutic use)</term><term>Thiobarbituric Acid Reactive Substances (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antioxydants (usage thérapeutique)</term><term>Association de médicaments</term><term>Cytochrome P-450 enzyme system (métabolisme)</term><term>Infections à Orthomyxoviridae (métabolisme)</term><term>Infections à Orthomyxoviridae (traitement médicamenteux)</term><term>Influenzavirus A (physiologie)</term><term>Microsomes du foie ()</term><term>Microsomes du foie (enzymologie)</term><term>Mixed function oxygenases (métabolisme)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>NADPH-ferrihemoprotéine reductase (métabolisme)</term><term>Peroxydation lipidique (physiologie)</term><term>Poumon (anatomopathologie)</term><term>Poumon (métabolisme)</term><term>Quercétine (usage thérapeutique)</term><term>Rutoside (usage thérapeutique)</term><term>Souris</term><term>Souris de lignée ICR</term><term>Stress oxydatif ()</term><term>Substances réactives à l'acide thiobarbiturique (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytochrome P-450 Enzyme System</term><term>Mixed Function Oxygenases</term><term>NADPH-Ferrihemoprotein Reductase</term><term>Thiobarbituric Acid Reactive Substances</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antioxidants</term><term>Quercetin</term><term>Rutin</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Microsomes, Liver</term><term>Oxidative 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xml:lang="en">The aim of this work is to study the effect of the flavonoids rutin and quercetin on hepatic monooxygenase activities in experimental influenza virus infection (EIVI). EIVI causes oxidative stress in the whole organism. This is confirmed by the rapidly increased concentrations of thiobarbituric reactive substances in influenza-infected mice: lungs - 290%; blood plasma - more than 320%; liver - 230%; brain - 50%. Although known for their antioxidant activities, rutin and quercetin exhibit prooxidant effect in healthy and antioxidant activity in influenza-infected animals. The pretreatment with both flavonoids (20 mg/kg b.w.) restores oxidative damage mostly in the target organ of the infection as well as in the liver of all infected mice (lungs: rutin - 30%, quercetin - 40%, combination - 45%; liver: rutin - 12%; quercetin - 40%; combination - 50%). As far as EIVI causes oxidative stress, toxicosis and inhibition of the hepatic monooxygenase activity, it is important to study the effects of rutin and quercetin on these systems. Both flavonoids induce the level of cytochrome P-450 (rutin - 13%, quercetin - 30%, combination - 22%) but inactivate NADPH-cytochrome c reductase, aminopyrine N-demethylase and analgin N-demethylase on the 5th day of EIVI. Probably, these flavonoids affect different components of the monooxygenase system. These effects could be explained with oxidative hepatic intoxication on the 5th critical day of EIVI as well as higher dose treatment. More data are needed on the antioxidant/prooxidant effects of rutin and quercetin, probably due to specific metabolic and physiological activities, chemical structure, etc.</div></front></TEI><affiliations><list><country><li>Bulgarie</li></country><region><li>Sofia-ville (oblast)</li></region><settlement><li>Sofia</li></settlement></list><tree><noCountry><name sortKey="Braykova, Ana A" sort="Braykova, Ana A" uniqKey="Braykova A" first="Ana A" last="Braykova">Ana A. Braykova</name><name sortKey="Galabov, Angel S" sort="Galabov, Angel S" uniqKey="Galabov A" first="Angel S" last="Galabov">Angel S. Galabov</name><name sortKey="Mileva, Milka M" sort="Mileva, Milka M" uniqKey="Mileva M" first="Milka M" last="Mileva">Milka M. Mileva</name><name sortKey="Pavlova, Elitsa L" sort="Pavlova, Elitsa L" uniqKey="Pavlova E" first="Elitsa L" last="Pavlova">Elitsa L. Pavlova</name><name sortKey="Stoeva, Emilia S" sort="Stoeva, Emilia S" uniqKey="Stoeva E" first="Emilia S" last="Stoeva">Emilia S. Stoeva</name><name sortKey="Tantcheva, Lyubka P" sort="Tantcheva, Lyubka P" uniqKey="Tantcheva L" first="Lyubka P" last="Tantcheva">Lyubka P. Tantcheva</name></noCountry><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Savov, Varban M" sort="Savov, Varban M" uniqKey="Savov V" first="Varban M" last="Savov">Varban M. Savov</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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